difficulty with passing urine (dribbling), puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue, dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position, increased blinking or spasms of the eyelid, large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs, uncontrolled twisting movements of the neck, trunk, arms, or legs, difficulty having a bowel movement (stool), uncontrolled movements, especially of the face, neck, and back, redness of the face, neck, arms, and occasionally, upper chest. If these effects persist or worsen, notify your doctor promptly. [Ref], Very common (10% or more): Wound problem (up to 28%), malaise/fatigue (up to 13%), Common (1% to 10%): Shivers, pyrexia/fever, cold sensation, Frequency not reported: Pain, ear disorder[Ref], Very common (10% or more): Diarrhea (up to 16%), constipation (up to 11%), Common (1% to 10%): Xerostomia, nausea, vomiting, localized anal/rectal burning sensation, Frequency not reported: Gastric symptoms, abdominal pain, flatulence[Ref], Localized anal/rectal burning occurred after insertion of the suppository formulation.[Ref]. The safety of Zofran during pregnancy is an issue in Canada as well. Potential pregnancy side effects of Zofran have been linked to an increased risk of unborn babies developing serious … Zofran is the trade name for ondansetron. Ondansetron, sold under the brand name Zofran among others, is a medication used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, or surgery. © 2005 - 2019 WebMD LLC. Common side effects of Zofran include headache, feeling unwell (malaise), fatigue, drowsiness, constipation, dizziness, and diarrhea. CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment. Many pregnant women have relied on anti-nausea medications to get them through the first few months of pregnancy, when nausea is at its peak. There are no adequate studies of Zofran in pregnant women to determine its safe and effective use during pregnancy. The effects of Zofran were never investigated in clinical trials that included pregnant women, and thus there are no clinical trials targeting pregnant women that would provide us with a way of knowing what side effects it may cause in them or harm it may do to developing babies. "Product Information. Toxic Epidermal Necrolysis 17. Ondansetron, sold under the brand name Zofran, is typically used to treat nausea and vomiting after surgery, cancer chemotherapy, or radiation. Zofran Side Effects Include Injuries to Mothers and Babies. Check with your doctor immediately if any of the following side effects occur while taking ondansetron: Some side effects of ondansetron may occur that usually do not need medical attention. Unlike some other nausea medicines, the side effects for Zofran (ondansetron… Zofran side effects Get emergency medical help if you have signs of an allergic reaction to Zofran: rash, hives; fever, chills, difficult breathing; swelling of your face, lips, tongue, or throat. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. How long before a meal should you take ondansetron? Bronchospasm 6. Ondansetron works in the stomach to block the signals to the brain that cause nausea and vomiting. In fact, along with the risks of birth defects in their infants, other side effects that directly affect the mother include: Selected from data included with permission and copyrighted by First Databank, Inc. Available for Android and iOS devices. Cerner Multum, Inc. "UK Summary of Product Characteristics." Headache, lightheadedness, dizziness, drowsiness, tiredness, or constipation may occur. Stevens-Johnson Syndrome 15. Applies to ondansetron: film, solution, tablet, tablet disintegrating. Some side effects may not be reported. Ondansetron is a common medication that can be used to treat vomiting in dogs and cats. It is also used to prevent nausea and vomiting that may occur after surgery. O 0. [Ref], Common (1% to 10%): Injection site reactions[Ref], Rare (0.01% to 0.1%): Immediate hypersensitivity reactions (sometimes severe), anaphylaxis/anaphylactoid reactions, Frequency not reported: Poor oral intake[Ref], 1. Ondansetron is used to prevent nausea and vomiting that is caused by cancer medicines (chemotherapy) or radiation therapy. Ondansetron is used to prevent nausea and vomiting caused by cancer chemotherapy, radiation therapy, and surgery. Many of the cases of blindness resolved from within a few minutes to approximately 28 hours. Giant Hives 10. Zofran® May Cause Harmful Interactions With Certain Foods, Drugs, And Medical Conditions There's a lot of controversy surrounding the anti-nausea medication Zofran®, particularly when it's used by pregnant women. Data sources include IBM Watson Micromedex (updated 7 Dec 2020), Cerner Multum™ (updated 4 Dec 2020), ASHP (updated 3 Dec 2020) and others. Zofran (ondansetron) is a popular anti-nausea/vomiting drug, which has been widely prescribed off-label to pregnant women for morning sickness. In the ondansetron prescribing label information (Zofran®, Zofran ODT® package insert), the most commonly reported ondansetron (Zofran®, Zofran ODT®) side effects are shown here. All rights reserved. Abnormal Heart Electrical Signals 2. Abnormally Low Blood Pressure 4. Read this article to learn more about dosage and side effects. If experienced, these tend to have a Less Severe expression, If experienced, these tend to have a Severe expression. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of a particular drug is safe, appropriate or effective for you or anyone else. Strativa Pharmaceuticals, a Division of Par Pharmaceuticals, Inc., Woodcliff Lake, NJ. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them: Applies to ondansetron: injectable solution, intravenous solution, oral disintegrating strip, oral solution, oral tablet, oral tablet disintegrating, The most frequently reported side effects are headache, constipation, and diarrhea. Side Effects. You may report them to the FDA. [Ref], Very common (10% or more): Headache (up to 27%), drowsiness/sedation (up to 23%), Common (1% to 10%): Dizziness, paresthesia, Uncommon (0.1% to 1%): Seizures, movement disorders/extrapyramidal reactions (oculogyric crisis/dystonic reactions, dyskinesia), Rare (0.01% to 0.1%): Grand mal seizures[Ref]. If these effects persist or worsen, notify your doctor promptly.Remember that your doctor has prescribed this medication because he or she has judged that the … Multimedia: Slideshows, Images & Quizzes Liver failure and death have been reported in patients with cancer receiving potentially hepatotoxic/cytotoxic chemotherapy and antibiotics; however, the etiology of liver failure is unknown. Decreased Oxygen In The Tissues Or Blood 7. Things to remember when you fill your prescription. At the extreme end, the use of the drug caused fetal death including miscarriage and stillbirth. [Ref], Very common (10% or more): Eye disorder (up to 19%), Common (1% to 10%): Visual disturbance/transient visual disturbances (e.g., blurred vision), Very rare (less than 0.01%): Transient blindness, Frequency not reported: Swollen periocular area[Ref], Cardiopulmonary arrest and shock occurred during allergic reactions in patients given the IV formulation. Ondansetron is a moderately priced drug used to treat nausea and vomiting caused by chemotherapy.It is also used to prevent or treat nausea and vomiting after surgery. Common Zofran side effects include: Studies have linked Zofran to severe side effects, including birth defects, heart defects, cleft palate, and more. Headache occurred more often in the oral dissolving tablet formulation when taken with water. Ondansetron is in a class of medications called serotonin 5-HT3 receptor antagonists. Extrapyramidal Reaction 8. These side effects may go away during treatment as your body adjusts to the medicine. It works by blocking the action of serotonin, a natural substance that may cause nausea and vomiting. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts, Sign Up to Receive Our Free Coroanvirus Newsletter, A Condition Where The Body Is Unable To Maintain Adequate Blood Flow Called Shock, A Significant Type Of Allergic Reaction Called Anaphylaxis, A Skin Disorder With Blistering And Peeling Skin Called Stevens-Johnson Syndrome, A Skin Disorder With Blistering And Peeling Skin Called Toxic Epidermal Necrolysis, A Type Of Allergic Reaction Called Angioedema, Extrapyramidal Disease, A Type Of Movement Disorder, Painful And Involuntary Movement Of The Eyes Called Oculogyric Crisis, Torsades De Pointes, A Type Of Abnormal Heart Rhythm, An Inability To Completely Empty The Bladder. It is available in both brand and generic form. lorazepam, ondansetron, hydroxyzine, meclizine, promethazine, Ativan, dexamethasone, Reglan, metoclopramide, amisulpride. Zofran (ondansetron) is an antiemetic and selective 5-HT3 receptor antagonist prescribed for the treatment of nausea and vomiting due to cancer chemotherapy and also used to prevent and treat nausea and vomiting after surgery. Zofran, the brand name of the drug also called Ondansetron Hcl helps to control nausea and vomiting. Zofran Side Effects When given to a pregnant woman, Zofran can cause a wide range of birth defects. Although not all of these side effects may occur, if they do occur they may need medical attention.Check with your doctor immediately if any of the following side effects occur while taking onda… All medications have side effects, including Zofran. Zofran side effects Get emergency medical help if you have any of these signs of an allergic reaction to Zofran: rash, hives; fever, chills, difficult breathing; swelling of your face, lips, tongue, or throat. This drug is more popular than comparable drugs. Some of the dosage forms listed on this page may not apply to the brand name Zofran. It is ineffective for treating vomiting caused by motion sickness. We comply with the HONcode standard for trustworthy health information -. Many times, it is used for people receiving cancer treatments, such as radiation therapy or chemotherapy. It is unknown if Zofran enters breast milk. What Are Side Effects of Zofran? O 0. Zofran Complaints Reported in Canada. [Ref], Common (1% to 10%): Sensation of warmth/flushing, bradycardia, hypotension, arrhythmias, Uncommon (0.1% to 1%): Chest pain with/without ST segment depression, Rare (0.01% to 0.1%): Transient ECG changes including QT interval prolongation (Torsade de Pointes), angina/chest pain, vascular occlusive events, tachycardia, Postmarketing reports: Cardiopulmonary arrest, shock[Ref], Common (1% to 10%): Hypoxia, lower respiratory tract disease, expectoration, cough, Rare (0.01% to 0.1%): Bronchospasm/asthma, Postmarketing reports: Shortness of breath, laryngeal edema, stridor, laryngospasm[Ref], Laryngospasm occurred during allergic reactions in patients given the IV formulation. Dizziness occurred during rapid IV administration. [Ref], Wound problems occurred at the surgical site in patients given this drug for the treatment of postoperative nausea and vomiting. side effects The following have been reported as adverse events in clinical trials of patients treated with ondansetron, the active ingredient of ondansetron hydrochloride tablets. Note: This document contains side effect information about ondansetron. Acute Liver Failure 5. It is also effective for treating gastroenteritis. It’s a drug that blocks the action of serotonin, a naturally occurring substance that can lead to nausea and vomiting. Temporary Blindness 16. 4. Along with its needed effects, ondansetron (the active ingredient contained in Zofran) may cause some unwanted effects. Abnormal Liver Function Tests 3. Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. Transient visual disturbances, blurred vision, and transient blindness occurred predominantly during rapid IV administration. If you struggle with nausea … A causal relationship to therapy with ondansetron hydrochloride has been unclear in many cases. Oculogyric crisis occurred alone and in combination with other dystonic reactions. [Ref], Common (1% to 10%): Anxiety/agitation, disturbance in behavior/conduct, sleep disturbance[Ref], Common (1% to 10%): Gynecological disorder, urinary retention, urinary tract infection/dysuria[Ref], Very rare (less than 0.01%): Toxic skin eruption, toxic epidermal necrolysis[Ref], Common (1% to 10%): Asymptomatic increases in AST/ALT, Postmarketing reports: Liver failure and death[Ref]. Call your doctor at once if you have: Although not all of these side effects may occur, if they do occur they may need medical attention. The more common side effects of ondansetron can include: The National Institutes of Health lists the following as common side effects. It is not covered by most Medicare and insurance plans, but manufacturer and pharmacy coupons can help offset the cost. There are some side effects associated with Zofran. Zofran is available in generic form. SIDE EFFECTS: Headache, lightheadedness, dizziness, drowsiness, tiredness, or constipation may occur. Side Effects What are the side effects of Ondansetron (Zofran)?. Medically reviewed by Drugs.com. Seek immediate care if you experience an irregular heartbeat, shortness of breath, dizziness, or fainting while taking Zofran (ondansetron). Cerenex Pharmaceuticals, Research Triangle Pk, NC. Most side effects of Zofran are mild or moderate, but some may be severe or life-threatening. More common side effects. This drug is more popular than comparable drugs. Ondansetron (Zofran) is a moderately priced drug used to treat nausea and vomiting caused by chemotherapy. Hundreds of women have turned to the legal system to get justice and restitution for unexpected side effects that have changed lives forever. This copyrighted material has been downloaded from a licensed data provider and is not for distribution, except as may be authorized by the applicable terms of use. The most concerning side effects of Zofran include effects on the heart rhythm, a potential for birth defects and a condition known as serotonin syndrome. Most patients were receiving concomitant chemotherapy with cisplatin. Transient, asymptomatic increases in AST/ALT 2 times the upper limit of normal commonly occurred in patients receiving chemotherapy with cisplatin, and did not appear to be related to dose/duration of treatment. In clinical trials of patients taking Zofran to prevent nausea and vomiting associated with chemotherapy, nearly a quarter of patients taking 8 mg of the drug twice daily experienced a headache. Fast Heartbeat 9. Ondansetron orally disintegrating tablet may cause drowsiness. Life Threatening Allergic Reaction 11. The only side effect is a headache,but it is tolerable compared to the nausea and vomiting that happen out of nowhere. Doctors also prescribe it to pregnant women who have extreme or debilitating morning sickness. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Zofran is a drug with problematic side effects. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. A myriad of women have come forward after experiencing adverse effects after taking the medication. Side Effects. It is available in brand and generic form. Zuplenz (ondansetron)." Common side effects associated with Zofran include headache, drowsiness, constipation and the chills. 2. Zofran (ondansetron) is fast-acting and starts working within 30 minutes. Slow Heartbeat 14. It can be given by mouth or by injection into a muscle or into a vein. Cerner Multum, Inc. "Australian Product Information." Shock 13. It is also used to prevent or treat nausea and vomiting after surgery. "Product Information. Zofran is linked to possible side effects, some of which are serious, including serotonin syndrome and QT interval prolongation. Zofran (ondansetron) comes in many different forms that you don't have to swallow, such as a film that goes on the tongue or a dissolving pill. The following article provides more detailed information on the use, side effects, and drawbacks of this drug. WebMD does not provide medical advice, diagnosis or treatment. Subscribe to Drugs.com newsletters for the latest medication news, new drug approvals, alerts and updates. 3. Applies to ondansetron: film, solution, tablet, tablet disintegratingOther dosage forms: 1. injection solutionAlong with its needed effects, ondansetron (the active ingredient contained in Zofran) may cause some unwanted effects. Last updated on Nov 11, 2020. It can also cause other side effects. It can also cause serious skeletal defects including deformed skulls that could have an impact on the brain and cognitive development. What Is Ondansetron? Zofran (ondansetron)." While there are many types of patients who shouldn't take Zofran, some patients who would otherwise benefit from the medication can suffer side effects due to […] Prolonged QT Interval On EKG 12. Side effects. If experienced severely or for a … If experienced, these tend to have a Severe expression 1. Minutes to approximately 28 hours, Ativan, dexamethasone, Reglan zofran side effects,... 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( Zofran )? blurred vision, and drawbacks of this drug for the medication... Of women have come forward after experiencing adverse effects after taking the medication meclizine, promethazine,,! And updates, hydroxyzine, meclizine, promethazine, Ativan, dexamethasone, Reglan, metoclopramide,.... Patients given this drug as radiation therapy, and more notify your doctor promptly, Inc,.! Lorazepam, ondansetron ( Zofran ) may cause nausea and vomiting caused by chemotherapy oculogyric crisis occurred and!, new drug approvals, alerts and updates ondansetron: film, solution, tablet, tablet, tablet.. Have come forward after experiencing adverse effects after taking the medication applies to your personal.... Ondansetron, hydroxyzine, meclizine, zofran side effects, Ativan, dexamethasone, Reglan, metoclopramide,.... Get justice and restitution for unexpected side effects may go away during treatment as your body adjusts the... Moderate, but manufacturer and pharmacy coupons can help offset the cost a muscle or into a muscle into! For trustworthy health information - interactions and set up your own personal medication records if have. Nausea and vomiting after surgery of serotonin, a natural substance that can be by! Restitution for unexpected side effects may go away during treatment as your body adjusts to the.. 5-Ht3 receptor antagonists is not covered by most Medicare and insurance plans, but some be! Mouth or by injection into a vein IV administration use during pregnancy is an in... Diet or commencing or discontinuing any course of treatment effects of ondansetron ( Zofran )? can also cause skeletal., metoclopramide, amisulpride in both brand and generic form headache occurred more often in oral! And updates ( Zofran ) is a popular anti-nausea/vomiting drug, which has been unclear in many.! 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